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Understanding the Connection Between POTS, Fibromyalgia & ME/CFS

Updated: Jul 10

Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are complex conditions that affect millions of people worldwide. They are characterized by a range of symptoms including chronic pain, fatigue, cognitive difficulties, and more. In recent years, another condition has been increasingly recognized in association with both Fibromyalgia and ME/CFS: Postural Orthostatic Tachycardia Syndrome (POTS). Understanding the relationship between POTS and these conditions is crucial for proper management and treatment.


What is POTS?

Postural Orthostatic Tachycardia Syndrome (POTS) is a condition characterized by an abnormal increase in heart rate that occurs after sitting up or standing. Normally, when we stand up, our body adjusts to maintain blood pressure and heart rate. However, in individuals with POTS, this regulation mechanism is dysfunctional, leading to symptoms such as lightheadedness, palpitations, fatigue, and fainting.



The Connection with Fibromyalgia and ME/CFS

While the exact cause of POTS is not fully understood, there appears to be a significant overlap between POTS and conditions like Fibromyalgia and ME/CFS. Research suggests that up to 25-50% of individuals with Fibromyalgia or ME/CFS also experience symptoms of POTS.


One hypothesis is that all three conditions share a common underlying mechanism involving dysregulation of the autonomic nervous system (ANS). The ANS controls involuntary bodily functions such as heart rate, blood pressure, digestion, and temperature regulation. Dysfunction in the ANS can lead to symptoms seen in POTS, Fibromyalgia, and ME/CFS.


Symptoms and Impact on Daily Life

The symptoms of POTS can be debilitating and significantly impact a person's quality of life. In addition to the hallmark symptoms of rapid heartbeat upon standing, individuals with POTS often experience fatigue, dizziness, brain fog, nausea, headaches, and difficulty exercising. These symptoms can make everyday activities challenging and can lead to social isolation and depression.



Diagnosis

Diagnosing POTS can be challenging due to its overlapping symptoms with other conditions like Fibromyalgia and ME/CFS. A tilt table test, where a patient's heart rate and blood pressure are monitored while lying flat and then tilted upright, is often used to diagnose POTS.


Conclusion

The relationship between POTS and conditions like Fibromyalgia and ME/CFS highlights the complexity of these illnesses and underscores the importance of a multidisciplinary approach to diagnosis and treatment. More research is needed to better understand the underlying mechanisms linking these conditions and to develop more effective treatments.


If you suspect you may have POTS or are experiencing symptoms similar to those described, it is important to consult with a healthcare professional for proper evaluation and management. By raising awareness and increasing understanding of these conditions, we can better support individuals living with POTS, Fibromyalgia, ME/CFS, and other related illnesses.


References

Raj, S. R. (2013). Postural tachycardia syndrome (POTS). Circulation, 127(23), 2336-2342.

Freeman, R., et al. (2011). Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Autonomic Neuroscience, 161(1-2), 46-48.

Newton, J. L., et al. (2007). Fatigue in primary biliary cirrhosis is associated with postural hypotension. Gut, 56(6), 806-809.

Schondorf, R., & Freeman, R. (1999). The importance of orthostatic intolerance in the chronic fatigue syndrome. American Journal of Medicine, 105(3), 90-96.

Benarroch, E. E. (2012). Postural tachycardia syndrome: a heterogeneous and multifactorial disorder. Mayo Clinic Proceedings, 87(12), 1214-1225.

Mallampalli, M. P., & Carter, C. L. (2014). Exploring sex and gender differences in sleep health: a Society for Women's Health Research Report. Journal of Women's Health, 23(7), 553-562.

Vernino, S., et al. (2001). Autonomic ganglia: target and novel therapeutic tool. Neurology, 56(4), 466-472.

Singer, W., et al. (2016). Acetylcholinesterase inhibition in POTS. Autonomic Neuroscience, 197, 58-68.

Sheldon, R. S., et al. (2015). 2015 Heart Rhythm Society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm, 12(6), e41-e63.

Loavenbruck, A. J., & Whitelaw, B. (2018). Dysautonomia and Its Relationship to POTS. Journal of Nurse Practitioners, 14(3), 173-178.

Raj, S. R., & Biaggioni, I. (2013). Diagnosis and Management of Postural Orthostatic Tachycardia Syndrome (POTS). A Guide for Clinicians. Springer.

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