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Writer's pictureFND Health

The Vicious Cycle of Sleep Deprivation and Chronic Conditions: A Closer Look

Updated: Aug 6

Sleep deprivation is a pervasive issue in modern society, affecting millions of people worldwide. It’s well-known that a lack of sleep can leave us feeling groggy and irritable, but the impacts run much deeper. Chronic sleep deprivation can have severe consequences on both our brains and bodies, leading to a myriad of health issues. This problem is even more pronounced for individuals suffering from chronic conditions such as fibromyalgia, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and Functional Neurological Disorder (FND). In these cases, sleep disturbances not only exacerbate symptoms but also create a vicious cycle that is difficult to break.


The Vicious Cycle of Sleep Deprivation and Chronic Conditions: A Closer Look

The Detrimental Effects of Sleep Deprivation


On the Brain:

  1. Cognitive Impairment: Lack of sleep significantly impairs cognitive functions, including attention, alertness, concentration, reasoning, and problem-solving. This can lead to decreased productivity and increased errors in daily tasks .

  2. Memory Issues: Sleep is crucial for memory consolidation. Without adequate sleep, the brain struggles to process and retain information, leading to forgetfulness and difficulty in learning new concepts .

  3. Emotional Instability: Sleep deprivation affects the brain’s ability to regulate emotions, resulting in heightened stress, anxiety, and depression. It can also lead to irritability and mood swings, impacting personal and professional relationships .


On the Body:

  1. Weakened Immune System: Chronic sleep deprivation weakens the immune system, making the body more susceptible to infections and illnesses .

  2. Increased Pain Sensitivity: Lack of sleep heightens the body’s sensitivity to pain. This is particularly problematic for individuals with chronic pain conditions, as their symptoms can become more severe .

  3. Cardiovascular Issues: Persistent sleep deprivation is linked to an increased risk of cardiovascular diseases, including hypertension, stroke, and heart attack .

  4. Metabolic Disruption: Poor sleep affects the body’s ability to regulate insulin, leading to an increased risk of diabetes. It also influences hunger hormones, often resulting in weight gain and obesity .


The Intersection of Sleep Deprivation and Chronic Conditions

For individuals with chronic conditions such as fibromyalgia, ME/CFS, and FND, sleep disturbances are a common and debilitating symptom. These conditions often involve complex interactions between the nervous, immune, and endocrine systems, making the management of symptoms particularly challenging.

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The Vicious Cycle

The relationship between sleep deprivation and chronic conditions is bidirectional. Chronic conditions often lead to sleep disturbances, which in turn exacerbate the symptoms of these conditions. This creates a vicious cycle:


  1. Pain and Discomfort: Chronic conditions cause pain and discomfort, making it difficult to sleep.

  2. Sleep Disturbances: Poor sleep quality and quantity lead to increased pain sensitivity and fatigue.

  3. Worsening Symptoms: The lack of restorative sleep exacerbates the symptoms of the chronic condition.

  4. Increased Stress and Anxiety: The worsening symptoms lead to increased stress and anxiety, further disrupting sleep.


The Vicious Cycle of Sleep Deprivation and Chronic Conditions: A Closer Look

The Biological Mechanisms Underlying Sleep and Chronic Conditions

According to the "Sleep, Sleep Disorders, and Biological Rhythms" report, sleep disturbances and chronic conditions share complex interrelated mechanisms:


  • Circadian Rhythm Disruption: Many chronic conditions disrupt the body's natural circadian rhythms, leading to irregular sleep patterns. This disruption can worsen symptoms and make it harder for patients to achieve restorative sleep​ (NCBI)​.

  • Neuroendocrine Dysregulation: Chronic pain and fatigue conditions often involve dysregulation of stress hormones like cortisol. Elevated cortisol levels, common in chronic conditions, can disturb sleep architecture and contribute to insomnia​ (NCBI)​.


Sleep Deprivation and Its Impact on Blood Sugar and Cortisol Levels

Sleep deprivation profoundly affects the body’s hormonal balance, particularly blood sugar and cortisol levels.


Blood Sugar Regulation:

  • Insulin Sensitivity: Lack of sleep impairs the body’s ability to use insulin effectively, leading to reduced insulin sensitivity and higher blood glucose levels. This condition, known as insulin resistance, is a precursor to type 2 diabetes​ (NCBI)​ .

  • Glucose Metabolism: Sleep deprivation can lead to disruptions in glucose metabolism, causing elevated blood sugar levels. This is due to a combination of decreased insulin sensitivity and an increase in cortisol levels, which promotes glucose production in the liver .


Cortisol Levels:

  • Stress Hormone Regulation: Cortisol, a hormone released in response to stress, follows a diurnal rhythm, peaking in the morning and declining throughout the day. Sleep deprivation disrupts this rhythm, leading to elevated cortisol levels at inappropriate times, which can exacerbate stress and further disturb sleep​ (NCBI)​.

  • Chronic Elevation: Persistent elevation of cortisol levels due to chronic sleep deprivation can lead to various health issues, including increased abdominal fat, high blood pressure, and impaired cognitive function​ (NCBI)​ .


Breaking this cycle is challenging but crucial for improving quality of life. Here are some strategies that might help:


1. Cognitive Behavioural Therapy for Insomnia (CBT-I): CBT-I is a structured program that helps individuals change thoughts and behaviours that contribute to sleep problems .

2. Medication: Under the guidance of a healthcare provider, medications can sometimes help manage pain and improve sleep .

3. Sleep Hygiene: Establishing a regular sleep schedule, creating a comfortable sleep environment, and avoiding stimulants before bedtime can promote better sleep .

4. Mind-Body Practices: Techniques such as mindfulness meditation, yoga, and deep-breathing exercises can help reduce stress and promote relaxation .

5. Physical Therapy and Gentle Exercise: Tailored physical therapy and gentle exercise routines can help manage pain and improve sleep quality .



The Significance of Dreams Involving Animal Pursuit in Medical Diagnosis

Dreams where one is being chased by animals can be more than just unsettling experiences; they might also serve as early indicators of certain medical conditions. Understanding the potential implications of these dreams can help in recognizing early symptoms and seeking appropriate medical advice.


Parkinson's Disease and REM Sleep Behaviour Disorder (RBD)

One notable association is with Parkinson's disease. Research has shown that vivid, aggressive dreams, including those where individuals are chased, can be linked to REM sleep behaviour disorder (RBD). RBD is a condition where the paralysis that typically occurs during REM sleep is incomplete or absent, allowing individuals to act out their dreams physically. These actions often involve violent or frantic behaviours. RBD can precede the motor symptoms of Parkinson's disease by several years, making these dreams a potential early warning sign of the disease.

Fibromyalgia and ME/CFS

Broader Implications

By recognizing and understanding the potential medical implications of these dreams, individuals can take proactive steps in managing their health and seeking early intervention when necessary.


In conclusion, the link between sleep deprivation and chronic conditions is profound and multifaceted. Addressing sleep disturbances is a critical component of managing chronic conditions and breaking the vicious cycle of worsening symptoms. By prioritizing sleep and seeking appropriate interventions, individuals can improve their overall health and well-being, paving the way for a better quality of life.



References

  1. Harvard Medical School. (2020). Sleep and Mental Health. Retrieved from Harvard Health

  2. Walker, M. P. (2017). Why We Sleep: Unlocking the Power of Sleep and Dreams. Scribner.

  3. National Institutes of Health. (2021). Memory and Sleep. Retrieved from NIH

  4. American Psychological Association. (2013). Why sleep is important and what happens when you don't get enough. Retrieved from APA

  5. Besedovsky, L., Lange, T., & Born, J. (2012). Sleep and immune function. Pflügers Archiv - European Journal of Physiology, 463(1), 121-137.

  6. Smith, M. T., & Haythornthwaite, J. A. (2004). How do sleep disturbance and chronic pain inter-relate? Insights from the longitudinal and cognitive-behavioral clinical trials literature. Sleep Medicine Reviews, 8(2), 119-132.

  7. Cappuccio, F. P., Cooper, D., D'Elia, L., Strazzullo, P., & Miller, M. A. (2011). Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. European Heart Journal, 32(12), 1484-1492.

  8. Knutson, K. L., & Van Cauter, E. (2008). Associations between sleep loss and increased risk of obesity and diabetes. Annals of the New York Academy of Sciences, 1129, 287-304.

  9. The National Fibromyalgia Association. (2021). Understanding Fibromyalgia. Retrieved from NFA

  10. Centers for Disease Control and Prevention. (2020). Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Retrieved from CDC

  11. Espay, A. J., Aybek, S., Carson, A., Edwards, M. J., Goldstein, L. H., Hallett, M., ... & Stone, J. (2018). Current concepts in diagnosis and treatment of functional neurological disorders. JAMA Neurology, 75(9), 1132-1141.

  12. Edinger, J. D., & Means, M. K. (2005). Cognitive-behavioral therapy for primary insomnia. Clinical Psychology Review, 25(5), 539-558.

  13. Morin, C. M., & Benca, R. (2012). Chronic insomnia. The Lancet, 379(9821), 1129-1141.

  14. Hirshkowitz, M., Whiton, K., Albert, S. M., Alessi, C., Bruni, O., DonCarlos, L., ... & Adams Hillard, P. J. (2015). National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health, 1(1), 40-43.

  15. Zeidan, F., Johnson, S. K., Gordon, N. S., & Goolkasian, P. (2010). Effects of brief and sham mindfulness meditation on mood and cardiovascular variables. Journal of Alternative and Complementary Medicine, 16(8), 867-873.

  16. Busch, A. J., Webber, S. C., Richards, R. S., Bidonde, J., Schachter, C. L., Schafer, L. A., ... & Danyliw, A. D. (2011). Resistance exercise training for fibromyalgia. Cochrane Database of Systematic Reviews, (12), CD010884.

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